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Priapism is a urological emergency characterized by abnormally prolonged, painful and irreducible erection. It occurs without a sexual stimulation and habitually exceeds 6 h. About a half of iatrogenic priapisms are believed to be associated with antipsychotics. Until to date, very few cases of aripiprazole-associated priapism were reported.

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In this case report, we present the clinical findings of a year-old patient that developed priapism after treatment with aripiprazole after his hospitalization for an episode of clinical mania following treatment discontinuation for bipolar I disorder. The management was successful and priapism was resolved spontaneously. Despite its low affinity to alpha-1 adrenergic receptors, aripiprazole may be associated with priapism.

Several potential factors involved in the pathogenesis of this adverse event have been reported in the literature including history of priapism in a different class of neuroleptics and consumption of psychoactive drugs which are the principal factors found in our case. Priapism may occur even during treatment with antipsychotics that have a low affinity to alpha1-adrenergic receptors. All patients on antipsychotics should be informed about the risk of this rare but serious adverse event. Despite its rareness, it remains an extremely serious condition that requires appropriate management.

Therefore, priapism is a medical and surgical emergency that may lead to severe sequelae, particularly, erectile dysfunction after fibrosis of the cavernous bodies [ 2 ]. However, there are few published cases in the literature that reported aripiprazole-induced priapism.

In this paper, we report a new case of this association in sex personal in sidi salah patient treated for bipolar I disorder based on CARE-guidelines [ 5 ]. Our patient is a 40 year-old male, married, father ofand working as a nurse.

A very rare case of priapism under aripiprazole in a patient followed for bipolar disorder: a care-compliant report

Cocaine was occasionally used. Moreover, he has a history of priapism induced by chlorpromazine during his hospitalization in for manic access. In that time, the management of his case required surgical intervention by puncture-washing of the cavernous bodies. After this adverse event, sedative neuroleptics were proscribed for him. Of note, our patient has no other personal or family history including psychiatric disorders.

During follow up, the occurrence of several relapses of manic and depressive symptoms were noticed which required his hospitalization with free intervals between episodes. The treatments changes were proposed to the patient because sex personal in sidi salah the marked adverse events reported principally sedation and priapism that needed his hospitalization in Inthe patient was admitted to our psychiatric hospital for psychomotor excitement, tachypsychia with logorrhea, mood lability, ideas of grandeur and multiple projects, which were associated with insomnia and a tendency to hetero aggressiveness.

According to DSM-V criteria, a mania in the context of bipolar I disorder following discontinuation of treatment for negative insight was retained as a diagnosis. Notably, there were no linguistic, cultural or financial issues during the management sex personal in sidi salah our patient. On day 10 of his hospitalization, the patient presented with a persistent and painful erection. He was referred to the urology department for management. A preliminary clinical assessment found no urological abnormalities.

The diagnosis of priapism induced by aripiprazole was therefore retained. The choice of this molecule was based on the good improvement and tolerance seen in the episodes as reported by the patient. The evolution was marked by the disappearance of manic symptoms, good tolerance, as well as non-recurrence of priapism. Despite the occurrence of aripiprazole-induced priapism is rare, its severity and difficult management should alert the attention of clinicians. Remarkably, a ificant strength of our clinical case is the absence of any drug interactions that might justify the association of other molecules with priapism.

In fact, our patient was treated with aripiprazole and diazepam only. Importantly, the recognition of this adverse event by the patient allowed us to intervene quickly. This is not always possible especially in patients with non-stabilized mental disorders.

The selection of an appropriate treatment for the patient sodium valproate was guided by the nature of his psychiatric disorder bipolar disorder type 1the response to this treatment and the absence of affinity for alphaadrenergic receptors. Therefore, this medication for this indication does not seem to increase the risk for developing priapism.

Several lines of evidence on the occurrence of priapism when using antipsychotics have supported the neuromuscular hypothesis that remained the most adopted worldwide. It suggests that antipsychotics-associated priapism depends on the ability of alphaadrenergic receptors blockade of the cavernous bodies [ 6 ].

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The current published literature reported several clinical cases of priapism associated with the two classes of antipsychotics including classical and atypical molecules [ 7 ]. In this perspective, haloperidol, chlorpromazine, levomepromazine and thioridazine are among the classical neuroleptics that have the greatest affinity for alpha-1 adrenergic receptors.

Clozapine, quetiapine, risperidone and olanzapine are the atypical antipsychotics with high affinity for these receptors [ [8][9][10] ]. However, aripiprazole has the lowest affinity for this receptor among all atypical antipsychotics [ 11 ] Table 1. Besides, despite this characteristic, cases of priapism induced by aripiprazole have been reported Table 2.

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Two reports suggested an association between the dose of aripiprazole and priapism [ 1213 ]. InMago et al. In addition, priapism has been reported when aripiprazole was combined with oxcarbazepine and lithium [ 15 ]. Other authors reported a case of priapism with 10 mg of aripiprazole within a few hours of its first sex personal in sidi salah to patients with schizophrenia [ 1617 ]. Our patient case differs from the rare reports published mainly by the nature of the underlying psychiatric disease. On the other hand, other common points are present. The repeated occurrence of priapism under different antipsychotics could refer to a predisposition to this adverse event [ 1819 ].

The use of psychoactive substances would also increase the risk of occurrence of priapism [ 20 ]. This was the case of our patient who is a chronic user of tobacco, cannabis and occasional cocaine.

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So far, the occurrence of priapism in our case does not appear to be dose related. In fact, our clinical case must attract the attention of practitioners to several key points. First, the systematic search for a history of priapism before administration of an antipsychotic should be performed because the literature raises cases of repeated priapism in these patients.

Furthermore, a careful follow up of patients treated with antipsychotics especially those who have unstable psychiatric diseases should be implemented. And finally, the use of antipsychotics with weak or absent alpha1-adrenergic affinity should be recommended along with psychoeducation.

During follow up, our patient was very satisfied with our management despite the stress experienced during his hospitalization for priapism. Priapism is a serious urological emergency that requires a rapid and an adequate management. The factors predisposing to its occurrence after aripiprazole use or other antipsychotics need to be evaluated in well conducted robust studies.

This will be essential to identify patients at risk to develop priapism. Patients under treatments using antipsychotics should be informed of the risk of this adverse event. Written informed consent was obtained from the patient for publication of this case report. A copy of the written consent is available for review by the Editor-in-Chief of this journal on request. Dr Salah-Eddine El Jabiry collected data and wrote the manuscript.

Dr Atif Mansour participated in the patient management. All the authors approved the final version. The following is the supplementary data related to this article:. National Center for Biotechnology InformationU. Ann Med Sex personal in sidi salah Lond. Published online Jan Author information Article notes Copyright and information Disclaimer. Salah-Eddine El Jabiry: am. Associated Data Supplementary Materials Multimedia component sex personal in sidi salah. Abstract Introduction and importance Priapism is a urological emergency characterized by abnormally prolonged, painful and irreducible erection.

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Case presentation In this case report, we present the clinical findings of a year-old patient that developed priapism after treatment with aripiprazole after his hospitalization for an episode of clinical mania following treatment discontinuation for bipolar I disorder.

Clinical discussion Despite its low affinity to alpha-1 adrenergic receptors, aripiprazole may be associated with priapism. Conclusion Priapism may occur even during treatment with antipsychotics that have a low affinity to alpha1-adrenergic receptors. Keywords: Priapism, Aripiprazole, Antipsychotics, alpha1-adrenergic receptors, Case report.

Presentation of case Our patient is a 40 year-old male, married, father ofand working as a nurse.

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Discussion Despite the occurrence of aripiprazole-induced priapism is rare, its severity and difficult management should alert the attention of clinicians. Table 1 Affinity of antipsychotics to alpha-1 adrenergic receptors. Open in a separate window. Table 2 Summary of published cases and reports on aripiprazole-associated priapism. Trivedi et al. Conclusion Priapism is a serious urological emergency that requires a rapid and an adequate management. Conflict of interest None declared.

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Sources of funding None. Consent Written informed consent was obtained from the patient for publication of this case report. Provenance and peer review Not commissioned, externally peer-reviewed. Appendix A. References 1. Ben jelloun S.

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